Exosomes

Role of extracellular matrix in cancer


BIOGRAPHY - SURESH MATHIVANAN

 









Suresh Mathivanan undertook a PhD in proteomics and bioinformatics at the Institute of Bioinformatics, India and Johns Hopkins University, USA. After PhD, Suresh joined Ludwig Institute for Cancer Research, Melbourne, Australia as a postdoctoral researcher.

In 2011, he received a NH&MRC Peter Doherty fellowship to study exosomes secreted by cancer cells. Further to this, in 2015, he received an ARC DECRA to study the role of exosomes in intercellular communication.

Suresh moved to the Department of Biochemistry, La Trobe Institute for Molecular Science (LIMS) at La Trobe University after receiving a LIMS fellowship to set up his own research group in 2011. At LIMS, Mathivanan's laboratory is focused on exosomes, their role in cancer and intercellular communication.




Academic Qualifications

2010 Ph.D. Biotechnology, Johns Hopkins University, Baltimore, MD, USA, and Kuvempu University, Karnataka, India



Awards

2015 Victorian Tall Poppy Award
2015 ARC DECRA (2015-2017)
2014 The Eppendorf Edman Award, ASBMB
2014 The Bioplatforms Australia Award, ASBMB
2014 Ken Mitchellhill Young Investigator Award, Australian Proteomics Society
2014 Ramaciotti Establishment Award
2013 Scopus Young Researcher Award (Finalist)
2013 Science Pathways Forum Award, La Trobe University
2011 NHMRC post-doctoral Training Fellowship (2011-2014)
2011 Young Investigator Award, 16th Proteomics Symposium, Australia
2011 Deans Award for Excellence in Research, La Trobe University
2010 Australian Proteomics Society Travel grant
2004 Fellowship from the Department of Biotechnology, India to pursue Advanced PG Diploma in Bioinformatics



Professional Activities

Associate Editor: Journal of Extracellular Vesicles
Editorial board member: International Journal of Cancer



SELECTED PUBLICATIONS

 


1. Chisanga, D., Keerthikumar, S., Pathan, M., Ariyaratne, D., Kalra, H., Boukouris, S., Mathew, N., Al Saffar, H., Gangoda, L., Ang, C.S., Sieber, O., Mariadason, J., Dasgupta, R., Chilamkurti, N. and Mathivanan, S. (2016) Colorectal Cancer Atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissue. Nucleic Acids Research. 44(D1), D969-74.

2. Keerthikumar, S., Gangoda, L., Liem, M., Fonseka, P., Atukorala, I., Ozcitti, C., Mechler, A., Adda, C.G., Ang, C.S. and Mathivanan, S. (2015) Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget. 17, 15375-15396.

3. Pathan, M., Keerthikumar, S., Ang, C.S., Gangoda, L., Quek, C.M.J., Williamson, N.J., Mouradov, D., Sieber, O.M., Simpson, R.J., Salim, A., Bacic, A., Hill, A.F., Stroud, D.A., Ryan, M.T., Agbinya, J.A., Mariadasson, J.M., Burgess, A.W. and Mathivanan, S. (2015) FunRich: a standalone tool for functional enrichment analysis. Proteomics. 15, 2597-2601.

4. Gangoda, L., Keerthikumar, S., Fonseka, P., Edgington, L.E., Ang, C.S., Ozcitti, C., Bogyo, M., Parker, B.S. and Mathivanan, S. (2015) Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin. Oncotarget. 6:13, 11175-11190.

5. Cooke, I., Jones, D., Bowen, J., Denge, C., Faou, P., Hall, N., Jayachandran, V., Liem, M., Taranto, A., Plummer, K.M. and Mathivanan, S. (2014) Proteogenomic analysis of the Venturia pirina (pear scab fungus) secretome reveals potential effectors. Journal of Proteome Research. 8, 3635-44

6. Kalra, H., Adda, C.G., Liem, M., Ang, C.S., Mechler, A., Simpson, R.J., Hulett, M.D. and Mathivanan, S. (2013) Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics. 22, 3354-64.

7. Kalra, H., Simpson, R.J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V.C., Borras, F.E., Breakefield, X., Budnik, V., Buzas, E., Camussi, G., Clayton, A., Cocucci, E., Falcon-Perez, J.M., Gabrielsson, S., Gho, Y.S., Gupta, D., Harsha, H.C., Hendrix, A., Hill, A.F., Inaal, J.M., Jenster, G., Kiang, L.S., Kramer-Albers, E-M., Llorente, A., Lotvall, J., Mincheva-Nilsson, L., Nazarenko, I., Nieuwland, R., Nolte-'t Hoen, E.N.M., Pandey, A., Patel, T., Piper, M.G., Pluchino, S., Prasad, T.S.K., Rajendran, L., Raposo, G., Record, M., Reid, G.E., Sanchez-Madrid, F., Schiffelers, R.M., Siljander, P., Stoorvogel, W., Taylor, D., Thery, C., Valadi, H., van Balkom, B.W.M., Vazquez, J., Vidal, M., Yanez-Mo, M., Zoeller, M. and Mathivanan, S. (2012) Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation. PLoS Biology. 12, e1001450.

      --- Nature Methods: Tools in brief - Introducing Vesiclepedia
      --- Journal of Extracellular Vesicles: Launch of Vesiclepedia

8. Mathivanan, S., Ji, H., Tauro, B.J., Chen, Y.S. and Simpson, R.J. (2012) Identifying mutated proteins secreted by colon cancer cell lines using mass spectrometry. Journal of Proteomics. 76, 141-9.

9. Mathivanan, S., Lim, J. W. E., Taro, B., Hong, J., Moritz, R. L. and Simpson, R. J. (2010). Proteomic analysis of A33-immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol Cell Proteomics. 2, 197-208.

10. Mathivanan, S. and Simpson, R. J. (2009). ExoCarta: A compendium of exosomal proteins and RNA. Proteomics. 9, 4997-5000.

11. Mathivanan, S., Ahmed, M. et al. (2008). Human Proteinpedia enables sharing of human protein data. Nature Biotechnology. 26, 164-7.

12. Amanchy, R., Periaswamy, B., Mathivanan, S., Reddy, R., Tattikota, S. G. and Pandey, A. (2007). A compendium of curated phosphorylation-based substrate and binding motifs. Nature Biotechnology. 25, 285-286.

13. Gandhi, T. K. B., Zhong, J., Mathivanan, S., Karthick, L., Chandrika, K. N., Mohan, S. S., Sharma, S., Pinkert, S., Nagaraju, S., Periaswamy, B., Mishra, G., Nandakumar, K., Shen, B., Deshpande, N., Nayak, R., Sarker, M., Boeke, J. D., Parmigiani, G., Schultz, J., Bader, J. S. and Pandey, A. (2006). Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nature Genetics. 3, 285-293.